INBIONET workshop at Trinity College Dublin

Feb ,14 2017

One month after the beginning of PhD I took part in the first INBIONET workshop on "immune evasion of pathogens" which was held at Trinity College Dublin .

Trinity College Dublin is one of the members of the INBIONET network. As clearly said, it is located in the capital of the republic of Ireland, Dublin. It is one of the world’s most prestigious academic institutions. The workshop was carried out in the lab of Pr Andrew Bowie. His research mainly focuses on poxviruses. He is investigating the role of PYHIN proteins in innate immunity, viral evasion of PRR signalling and characterising the role of mammalian SARM. Eleven people are part of his group (https://www.tcd.ie/Biochemistry/research/a_bowie.php).

Workshop consisted in talks from renowned researchers, about advanced topics in innate immune signalling (from basic mechanisms to pathogen detection and evasion). It covered several topics from the evasion from S.aureus, M.tuberculosis, poxviruses; antiviral interferon signalling and HCV, intracellular DNA sensing by the innate immune system, inflammasome or the vaccine adjuvants. These seminars were useful in the sense that all the fellows are involved in the field of infection and immunity.

In addition, two training units were performed, still in accordance with pathogen evasion. Indeed, the effects of pathogens on the activation of pattern recognition receptors (PRR) were assessed in aim to characterize genes responsible for immune evasion. Cellular biology techniques were used. Moreover, the level of activation of these PRR was measured by western blot following stimulation. This practical training was a good way to familiarize myself with these methods that I have never used and which are quite accurate to study interactions between hosts and pathogens.

To finish, a journalist specialised in sciences, delivered a speech about science towards non-scientists. Indeed, it can be struggling to talk about its own research to someone who has never done science. Therefore, a poster session has been organised to train ourselves, explaining our project in Lehmann’s terms.

As a conclusion, this workshop has brought me useful tools to start peacefully my PhD. I thank Marie Curie Actions for this good opportunity.